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Pfizer News, LinkedIn, YouTube and like us on Facebook at Facebook. Based on the mechanism of action, IBRANCE can cause fetal harm. IBRANCE when taken in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may increase their exposure. Advise women not to breastfeed during IBRANCE treatment and for 3 months after the last dose.

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